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Recapitulation of the Achilles tendon mechanical properties during neonatal development: a study of differential healing during two stages of development in a mouse model.
- Source :
-
Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2012 Mar; Vol. 30 (3), pp. 448-56. Date of Electronic Publication: 2011 Aug 24. - Publication Year :
- 2012
-
Abstract
- During neonatal development, tendons undergo a well-orchestrated process whereby extensive structural and compositional changes occur in synchrony to produce a normal tissue. Conversely, during the repair response to injury, structural and compositional changes occur, but a mechanically inferior tendon is produced. As a result, developmental processes have been postulated as a potential paradigm through which improved adult tissue healing may occur. By examining injury at distinctly different stages of development, vital information can be obtained into the structure-function relationships in tendon. The mouse is an intriguing developmental model due to the availability of assays and genetically altered animals. However, it has not previously been used for mechanical analysis of healing tendon due to the small size and fragile nature of neonatal tendons. The objective of this study was to evaluate the differential healing response in tendon at two distinct stages of development through mechanical, compositional, and structural properties. To accomplish this, a new in vivo surgical model and mechanical analysis method for the neonatal mouse Achilles tendons were developed. We demonstrated that injury during early development has an accelerated healing response when compared to injury during late development. This accelerated healing model can be used in future mechanistic studies to elucidate the method for improved adult tendon healing.<br /> (Copyright © 2011 Orthopaedic Research Society.)
- Subjects :
- Achilles Tendon pathology
Animals
Animals, Newborn
Biglycan metabolism
Cell Count
Cell Shape
Collagen metabolism
Decorin metabolism
Elastic Modulus
Mice
Mice, Inbred C57BL
RNA, Messenger metabolism
Stress, Mechanical
Tendon Injuries pathology
Achilles Tendon physiology
Aging physiology
Tendon Injuries physiopathology
Wound Healing physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1554-527X
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of orthopaedic research : official publication of the Orthopaedic Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 22267191
- Full Text :
- https://doi.org/10.1002/jor.21542