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Nanocomposite formation between alpha-glucosyl stevia and surfactant improves the dissolution profile of poorly water-soluble drug.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2012 May 30; Vol. 428 (1-2), pp. 183-6. Date of Electronic Publication: 2012 Jan 14. - Publication Year :
- 2012
-
Abstract
- The formation of a hybrid-nanocomposite using α-glucosyl stevia (Stevia-G) and surfactant was explored to improve the dissolution of flurbiprofen (FP). As reported previously, the dissolution amount of FP was enhanced in the presence of Stevia-G, induced by the formation of an FP and Stevia-G-associated nanostructure. When a small amount of sodium dodecyl sulfate (SDS) was present with Stevia-G, the amount of dissolved FP was extremely enhanced. This dissolution-enhancement effect was also observed with the cationic surfactant of dodecyl trimethyl ammonium bromide, but not with the non-ionic surfactant of n-octyl-β-D-maltopyranoside. To investigate the dissolution-enhancement effect of Stevia-G/SDS mixture, the pyrene I(1)/I(3) ratio was plotted versus the Stevia-G concentration. The pyrene I(1)/I(3) ratio of Stevia-G/SDS mixture had a sigmoidal curve at lower Stevia-G concentrations compared to the Stevia-G solution alone. These results indicate that the Stevia-G/SDS mixture provides a hydrophobic core around pyrene molecules at lower Stevia-G concentrations, leading to nanocomposite formation between Stevia-G and SDS. The nanocomposite of Stevia-G/SDS showed no cytotoxicity to Caco-2 cells at a mixture of 0.1% SDS and 1% Stevia-G solution, whereas 0.1% SDS solution showed high toxicity. These results suggest that the nanocomposite formation of Stevia-G/SDS may be useful way to enhance the dissolution of poorly water-soluble drugs without special treatment.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Caco-2 Cells
Humans
Hydrophobic and Hydrophilic Interactions
Maltose analogs & derivatives
Maltose chemistry
Micelles
Pyrenes chemistry
Quaternary Ammonium Compounds chemistry
Sodium Dodecyl Sulfate chemistry
Solubility
Thermodynamics
Flurbiprofen chemistry
Nanocomposites chemistry
Stevia chemistry
Surface-Active Agents chemistry
Water chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 428
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 22265914
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2012.01.016