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Regional differences in expression of β-tubulin isoforms in schizophrenia.
- Source :
-
Schizophrenia research [Schizophr Res] 2012 Mar; Vol. 135 (1-3), pp. 181-6. Date of Electronic Publication: 2012 Jan 20. - Publication Year :
- 2012
-
Abstract
- A growing body of evidence suggests that abnormal elements of the cytoskeleton may be associated with the pathophysiology of schizophrenia. Isoforms of a major cytoskeleton protein, β-tubulin, were recently demonstrated to have distinct roles in neuronal differentiation and cell viability. For these reasons, we tested the hypothesis that there are differences in the expression of β-tubulin isoforms (βI-βIV) in the brain in schizophrenia, using western blot analysis in an elderly group of subjects with this illness and a control group. We found that βI-tubulin protein expression was decreased in the anterior cingulate cortex and increased in the dorsolateral prefrontal cortex, but not changed in superior temporal gyrus or hippocampus in schizophrenia. Our data supports the growing body of evidence suggesting abnormalities of the cytoskeleton in schizophrenia.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Analysis of Variance
Brain pathology
Female
Hippocampus metabolism
Hippocampus pathology
Humans
Male
Middle Aged
Prefrontal Cortex metabolism
Prefrontal Cortex pathology
Protein Isoforms metabolism
Temporal Lobe metabolism
Temporal Lobe pathology
Brain metabolism
Schizophrenia pathology
Tubulin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2509
- Volume :
- 135
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Schizophrenia research
- Publication Type :
- Academic Journal
- Accession number :
- 22264600
- Full Text :
- https://doi.org/10.1016/j.schres.2011.12.010