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Serum vitamin D deficiency as a predictor of incident non-Alzheimer dementias: a 7-year longitudinal study.
- Source :
-
Dementia and geriatric cognitive disorders [Dement Geriatr Cogn Disord] 2011; Vol. 32 (4), pp. 273-8. Date of Electronic Publication: 2012 Jan 19. - Publication Year :
- 2011
-
Abstract
- Background: Hypovitaminosis D has been cross-sectionally associated with dementia and stroke. The objective of this longitudinal study was to determine whether serum vitamin D deficiency at baseline could predict the onset of non-Alzheimer dementias (NAD) within 7 years among older women.<br />Methods: Forty high-functioning older women (78.4 years, 76.4/82.0; median, 25th/75th percentile) from the EPIDOS Toulouse study were divided into two groups based on vitamin D deficiency (i.e., serum 25-hydroxyvitamin D <10 ng/ml) at baseline. At the end of the 7-year follow-up period, women matching the DSM-IV but not the NINCDS-ADRDA criteria were diagnosed with NAD while those matching the NINCDS-ADRDA criteria were considered to have Alzheimer's disease (AD). Subtle cognitive impairments at baseline, cardiovascular risk factors and Parkinson's disease were used as potential confounders.<br />Results: NAD was reported in 6 women (82.8 years, 80.6/86.0) after 7 years of follow-up. More NAD were observed in women with vitamin D deficiency (p = 0.023). There was no between-group difference regarding the onset of AD (p = 0.332). We found an association between vitamin D deficiency at baseline and the onset of NAD (adjusted odds ratio = 19.57, p = 0.042). Conversely, vitamin D deficiency was not associated with AD (p = 0.222).<br />Conclusion: Baseline vitamin D deficiency predicted the onset of NAD within 7 years among older women.<br /> (Copyright © 2012 S. Karger AG, Basel.)
- Subjects :
- Aged
Aged, 80 and over
Cohort Studies
Dementia complications
Diagnostic and Statistical Manual of Mental Disorders
Female
France
Humans
Logistic Models
Longitudinal Studies
Odds Ratio
Predictive Value of Tests
Prospective Studies
Risk Factors
Vitamin D blood
Vitamin D Deficiency complications
Vitamins blood
Dementia diagnosis
Vitamin D Deficiency diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9824
- Volume :
- 32
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Dementia and geriatric cognitive disorders
- Publication Type :
- Academic Journal
- Accession number :
- 22261995
- Full Text :
- https://doi.org/10.1159/000334944