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Effects of lidocaine constant rate infusion on sevoflurane requirement, autonomic responses, and postoperative analgesia in dogs undergoing ovariectomy under opioid-based balanced anesthesia.
- Source :
-
Veterinary journal (London, England : 1997) [Vet J] 2012 Aug; Vol. 193 (2), pp. 448-55. Date of Electronic Publication: 2012 Jan 17. - Publication Year :
- 2012
-
Abstract
- The effects of constant rate infusion (CRI) of lidocaine on sevoflurane (SEVO) requirements, autonomic responses to noxious stimulation, and postoperative pain relief were evaluated in dogs undergoing opioid-based balanced anesthesia. Twenty-four dogs scheduled for elective ovariectomy were randomly assigned to one of four groups: BC, receiving buprenorphine without lidocaine; FC, receiving fentanyl without lidocaine; BL, receiving buprenorphine and lidocaine; FL, receiving fentanyl and lidocaine. Dogs were anesthetized with intravenous (IV) diazepam and ketamine and anesthesia maintained with SEVO in oxygen/air. Lidocaine (2mg/kg plus 50 μg/kg/min) or saline were infused in groups BL/FL and BC/FC, respectively. After initiation of lidocaine or saline CRI IV buprenorphine (0.02 mg/kg) or fentanyl (4 μg/kg plus 8 μg/kg/h CRI) were administered IV in BC/BL and FC/FL, respectively. Respiratory and hemodynamic variables, drug plasma concentrations, and end-tidal SEVO concentrations (E'SEVO) were measured. Behaviors and pain scores were subjectively assessed 1 and 2h post-extubation. Lidocaine CRI produced median drug plasma concentrations <0.4 μg/mL during peak surgical stimulation. Lidocaine produced a 14% decrease in E'SEVO in the BL (P<0.01) but none in the FL group and no change in cardio-pulmonary responses to surgery or postoperative behaviors and pain scores in any group. Thus, depending on the opioid used, supplementing opioid-based balanced anesthesia with lidocaine (50 μg/kg/min) may not have any or only a minor impact on anesthetic outcome in terms of total anesthetic dose, autonomic responses to visceral nociception, and postoperative analgesia.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Analgesia veterinary
Anesthetics, Intravenous administration & dosage
Animals
Balanced Anesthesia veterinary
Buprenorphine administration & dosage
Dogs
Female
Fentanyl administration & dosage
Infusions, Intravenous veterinary
Ovariectomy veterinary
Pain, Postoperative drug therapy
Pain, Postoperative veterinary
Prospective Studies
Sevoflurane
Single-Blind Method
Analgesics, Opioid administration & dosage
Anesthetics, Inhalation administration & dosage
Anesthetics, Local administration & dosage
Balanced Anesthesia methods
Lidocaine administration & dosage
Methyl Ethers administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2971
- Volume :
- 193
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Veterinary journal (London, England : 1997)
- Publication Type :
- Academic Journal
- Accession number :
- 22261004
- Full Text :
- https://doi.org/10.1016/j.tvjl.2011.12.005