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Simultaneous PET/MR imaging in a human brain PET/MR system in 50 patients--current state of image quality.
- Source :
-
European journal of radiology [Eur J Radiol] 2012 Nov; Vol. 81 (11), pp. 3472-8. Date of Electronic Publication: 2012 Jan 18. - Publication Year :
- 2012
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Abstract
- Objectives: The present work illustrates the current state of image quality and diagnostic accuracy in a new hybrid BrainPET/MR.<br />Materials and Methods: 50 patients with intracranial masses, head and upper neck tumors or neurodegenerative diseases were examined with a hybrid BrainPET/MR consisting of a conventional 3T MR system and an MR-compatible PET insert. Directly before PET/MR, all patients underwent a PET/CT examination with either [18F]-FDG, [11C]-methionine or [68Ga]-DOTATOC. In addition to anatomical MR scans, functional sequences were performed including diffusion tensor imaging (DTI), arterial spin labeling (ASL) and proton-spectroscopy. Image quality score of MR imaging was evaluated using a 4-point-scale. PET data quality was assessed by evaluating FDG-uptake and tumor delineation with [11C]-methionine and [68Ga]-DOTATOC. FDG uptake quantification accuracy was evaluated by means of ROI analysis (right and left frontal and temporo-occipital lobes). The asymmetry indices and ratios between frontal and occipital ROIs were compared.<br />Results: In 45/50 patients, PET/MR examination was successful. Visual analysis revealed a diagnostic image quality of anatomical MR imaging (mean quality score T2 FSE: 1.27±0.54; FLAIR: 1.38±0.61). ASL and proton-spectroscopy was possible in all cases. In DTI, dental artifacts lead to one non-diagnostic dataset (mean quality score DTI: 1.32±0.69; ASL: 1.10±0.31). PET datasets of PET/MR and PET/CT offered comparable tumor delineation with [11C]-methionine; additional lesions were found in 2/8 [(68)Ga]-DOTATOC-PET in the PET/MR. Mean asymmetry index revealed a high accordance between PET/MR and PET/CT (1.5±2.2% vs. 0.9±3.6%; mean ratio (frontal/parieto-occipital) 0.93±0.08 vs. 0.96±0.05), respectively.<br />Conclusions: The hybrid BrainPET/MR allows for molecular, anatomical and functional imaging with uncompromised MR image quality and a high accordance of PET results between PET/MR and PET/CT. These results justify the application of this technique in further clinical studies and may contribute to the transfer into whole-body PET/MR systems.<br /> (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Equipment Design trends
Equipment Failure Analysis
Female
Humans
Magnetic Resonance Imaging trends
Male
Middle Aged
Positron-Emission Tomography trends
Reproducibility of Results
Sensitivity and Specificity
Subtraction Technique trends
Young Adult
Brain Neoplasms diagnosis
Head and Neck Neoplasms diagnosis
Magnetic Resonance Imaging instrumentation
Positron-Emission Tomography instrumentation
Subtraction Technique instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7727
- Volume :
- 81
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- European journal of radiology
- Publication Type :
- Academic Journal
- Accession number :
- 22260898
- Full Text :
- https://doi.org/10.1016/j.ejrad.2011.12.027