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Early-onset absence epilepsy at eight months of age.
- Source :
-
Epileptic disorders : international epilepsy journal with videotape [Epileptic Disord] 2011 Dec; Vol. 13 (4), pp. 417-21. - Publication Year :
- 2011
-
Abstract
- Early-onset absence epilepsy refers to patients with absence seizures beginning before age four and comprises a heterogeneous group of epilepsies. Onset of absence seizures in the first year of life is very rare. We report a girl with intractable absence seizures with onset at age eight months. Her seizures were characterised by loss of responsiveness, with eyes drifting upwards and some myoclonic jerks of the upper and lower limbs. These symptoms were accompanied by bilaterally symmetric high-amplitude 2-2.5 Hz generalised spike-and-wave discharges on the electroencephalogram. Her seizures were refractory to conventional antiepileptic drugs; treatment with adrenocorticotropic hormone was transiently effective. Comprehensive metabolic screening, cytogenetic, and genetic analysis did not determine an underlying cause of her condition. Patients with intractable, very early-onset absence epilepsy with a myoclonic component have an unfavourable outcome and may be classified under a new epileptic syndrome, such as "early infantile absence epilepsy".
- Subjects :
- Adrenocorticotropic Hormone therapeutic use
Adult
Age of Onset
Anticonvulsants therapeutic use
Developmental Disabilities complications
Drug Resistance
Electroencephalography drug effects
Epilepsy, Absence complications
Epilepsy, Absence drug therapy
Female
Humans
Infant
Pregnancy
Recurrence
Seizures physiopathology
Seizures psychology
Treatment Outcome
Epilepsy, Absence physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1294-9361
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Epileptic disorders : international epilepsy journal with videotape
- Publication Type :
- Academic Journal
- Accession number :
- 22258047
- Full Text :
- https://doi.org/10.1684/epd.2011.0477