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Disruption of memory reconsolidation impairs storage of other, non-reactivated memory.
- Source :
-
Neurobiology of learning and memory [Neurobiol Learn Mem] 2012 Feb; Vol. 97 (2), pp. 241-9. Date of Electronic Publication: 2012 Jan 12. - Publication Year :
- 2012
-
Abstract
- Two hypotheses were tested in this study. First, blockade of neural activity by lidocaine immediately following the retrieval of a memory may impair the reconsolidation and subsequent expression of that memory. Second, a non-retrieved memory would not be affected by this lidocaine treatment. Since the basolateral nucleus of the amygdala (BLA) is involved in emotion-related memory, an intra-BLA lidocaine infusion was used immediately after the retrieval of two emotion-related memories, the step-through passive avoidance response (PA) and cocaine-induced conditioned place preference (CPP). Intra-BLA lidocaine infusion immediately after cocaine-induced CPP retrieval diminished CPP magnitude in retests. However, intra-BLA lidocaine infusion alone did not affect cocaine-induced CPP performance. Intra-BLA lidocaine infusion immediately after PA retrieval decreased PA performance in retests. Omission of PA retrieval procedure, intra-BLA lidocaine infusion did not affect subsequent PA performance. Surprisingly, intra-BLA lidocaine infusion immediately following the retrieval of PA or cocaine-induced CPP diminished both PA and cocaine-induced CPP performance in the retests. Finally, Fos-staining results revealed that a number of BLA neurons were activated by the retrieval of both cocaine-induced CPP and PA. We conclude that inactivation of neural activity in BLA immediately following retrieval of a fear or cocaine-conditioned memory can impair subsequent expression of both memories. More importantly, retrieval of a memory does not seem to be an absolute condition for rapidly changing the memory.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Subjects :
- Amygdala drug effects
Animals
Avoidance Learning drug effects
Cocaine pharmacology
Conditioning, Classical drug effects
Dopamine Uptake Inhibitors pharmacology
Emotions drug effects
Memory drug effects
Mice
Amygdala physiopathology
Avoidance Learning physiology
Conditioning, Classical physiology
Emotions physiology
Memory physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9564
- Volume :
- 97
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neurobiology of learning and memory
- Publication Type :
- Academic Journal
- Accession number :
- 22252051
- Full Text :
- https://doi.org/10.1016/j.nlm.2012.01.001