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Characteristics of serious complicated gastroduodenal ulcers in Japan.
- Source :
-
Hepato-gastroenterology [Hepatogastroenterology] 2012 Jan-Feb; Vol. 59 (113), pp. 147-54. - Publication Year :
- 2012
-
Abstract
- Background/aims: Even in Japan where the incidence of H. pylori infection is high, patients with gastroduodenal ulcers caused by NSAIDs are on the increase. A prospective study was conducted to elucidate the characteristics of gastroduodenal ulcers complicated with ulcerous hemorrhage and perforation among Japanese.<br />Methodology: The subjects were 305 consecutive cases with hemorrhaging ulcers and 76 consecutive cases with perforated ulcers basis at Kagawa Prefectural Central Hospital between January 2000 and December 2008. These subjects were divided into 3 groups (lowdose aspirin, non-aspirin NSAIDs and non-NSAIDs) and were further stratified by the presence of an H. pylori infection.<br />Results: The 76 perforating ulcers were composed of 54 non-NSAIDs ulcers and 22 NSAIDs-related ulcers. The 305 hemorrhaging ulcers were composed of 156 non-NSAIDs ulcers, 94 non-aspirin NSAIDs ulcers and 55 on low-dose aspirin. The mortality for the non-aspirin NSAIDs group (12.8%, 12/94) and for the low-dose aspirin group (10.9%, 6/55) was significantly higher (p<0.01 and p<0.05, respectively) than the corresponding figure (2.6%, 4/156) for the non-NSAIDs group. The causes of death were exacerbation of or complications from the background diseases (Charlson Co-morbidity Index 3≤) (Odds ratios (OR) 6.01, 95% CI (1.98-18.89)).<br />Conclusions: Approximately 50% of the gastroduodenal ulcers with complications found in Japanese are NSAIDs-related and may take a fatal turn. It is necessary to take measures to prevent the complicated ulcers corresponding to risk factors such as the severity of background diseases.
- Subjects :
- Aged
Aged, 80 and over
Chi-Square Distribution
Comorbidity
Female
Helicobacter Infections complications
Helicobacter Infections microbiology
Helicobacter pylori isolation & purification
Humans
Japan epidemiology
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Peptic Ulcer microbiology
Peptic Ulcer mortality
Peptic Ulcer pathology
Peptic Ulcer Hemorrhage microbiology
Peptic Ulcer Hemorrhage mortality
Peptic Ulcer Hemorrhage pathology
Prospective Studies
Risk Assessment
Risk Factors
Time Factors
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Peptic Ulcer chemically induced
Peptic Ulcer Hemorrhage chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0172-6390
- Volume :
- 59
- Issue :
- 113
- Database :
- MEDLINE
- Journal :
- Hepato-gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 22251530
- Full Text :
- https://doi.org/10.5754/hge09689