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[Sequence analysis subtyping of the 56-kDa protein-encoding gene of Karp-type Orientia tsutsugamushi isolated in scrub typhus cases].
- Source :
-
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases [Kansenshogaku Zasshi] 2011 Nov; Vol. 85 (6), pp. 626-31. - Publication Year :
- 2011
-
Abstract
- To determine the Karp-type Orientia tsutsugamushi subtype in northern Japan, i.e., Yamagata, Niigata, and Akita Prefectures, we analyzed the partial nucleotide sequence of the 56-kDa protein-encoding gene of 30 isolates from scrub typhus cases. Based on sequencing results, we classified isolates into two groups of 27 and 3 isolates. Nucleotide sequences of 27 isolates were homologous to the yeo-joo strain, classified as a JP-1 subtype. The three isolates were each homologous to a stain of CMM1, KNP1, or KNP2, classified as JP-2 subtypes. Phylogenetic tree analysis showed the 27 isolates forming a cluster with the yeo-joo strain and the three isolates with the CMM, KNP1, and KNP2 strains and therefore belonging to these subtypes. The Karp-type O. tsutsugamushi JP-2 subtype predominates in Japan, the JP-1 subtype probably the predominates in the area investigated. O. tsutsugamushi JP-1 subtype strains must therefore be isolated from subjects in this area and comprehensively studied.
Details
- Language :
- Japanese
- ISSN :
- 0387-5911
- Volume :
- 85
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 22250452
- Full Text :
- https://doi.org/10.11150/kansenshogakuzasshi.85.626