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Gingival crevicular fluid and plasma acute-phase cytokine levels in different periodontal diseases.
- Source :
-
Journal of periodontology [J Periodontol] 2012 Oct; Vol. 83 (10), pp. 1304-13. Date of Electronic Publication: 2012 Jan 16. - Publication Year :
- 2012
-
Abstract
- Background: The aim of the present study is to investigate gingival crevicular fluid (GCF) and plasma acute-phase cytokines, interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-11 (IL-11), oncostatin M (OSM), and leukemia inhibitory factor (LIF) levels in patients with different periodontal diseases.<br />Methods: Eighty individuals were included in this study; 20 with chronic periodontitis (CP), 20 with generalized aggressive periodontitis (GAgP), 20 with gingivitis, and 20 classified as healthy (H). Probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. Plasma and GCF IL-1β, IL-6, IL-11, OSM, and LIF levels were analyzed by enzyme-linked immunosorbent assay.<br />Results: CP and GAgP groups had significantly higher GCF IL-1β, IL-6, and IL-11 levels when compared with the H group (P <0.05). Conversely, GCF LIF levels of the CP and GAgP groups were lower than those of the H group (P <0.05). GCF OSM levels did not differ significantly among study groups. Plasma levels of all the cytokines studied were not significantly different among the study groups.<br />Conclusions: Based on the present data, elevated IL-1β, IL-6, and IL-11 GCF levels, but not plasma levels, are suggested as reliable inflammatory biomarkers in periodontal diseases. Decreased LIF levels in diseased groups might reflect the possible beneficial effects of LIF in the modulation of inflammatory response in gingiva.
- Subjects :
- Adult
Aggressive Periodontitis blood
Biomarkers blood
Case-Control Studies
Chronic Periodontitis blood
Cytokines blood
Female
Gingivitis blood
Humans
Interleukin-11 analysis
Interleukin-11 blood
Interleukin-1beta analysis
Interleukin-1beta blood
Interleukin-6 analysis
Interleukin-6 blood
Leukemia Inhibitory Factor analysis
Leukemia Inhibitory Factor blood
Male
Middle Aged
Oncostatin M analysis
Oncostatin M blood
Statistics, Nonparametric
Young Adult
Acute-Phase Proteins analysis
Aggressive Periodontitis metabolism
Biomarkers analysis
Chronic Periodontitis metabolism
Cytokines analysis
Gingival Crevicular Fluid chemistry
Gingivitis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1943-3670
- Volume :
- 83
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 22248224
- Full Text :
- https://doi.org/10.1902/jop.2012.110616