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Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFα enhances GPR84 expression in adipocytes.
- Source :
-
FEBS letters [FEBS Lett] 2012 Feb 17; Vol. 586 (4), pp. 368-72. Date of Electronic Publication: 2012 Jan 10. - Publication Year :
- 2012
-
Abstract
- In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.<br /> (Copyright © 2012 Federation of European Biochemical Societies. All rights reserved.)
- Subjects :
- 3T3-L1 Cells
Adipocytes drug effects
Adipocytes metabolism
Adiponectin genetics
Animals
Cell Line
Coculture Techniques
Decanoic Acids pharmacology
Fatty Acids metabolism
Gene Expression drug effects
Inflammation metabolism
Ligands
Macrophages metabolism
Male
Mice
Mice, Inbred C57BL
RNA, Messenger genetics
RNA, Messenger metabolism
Receptors, G-Protein-Coupled metabolism
Adipose Tissue metabolism
Inflammation genetics
Receptors, G-Protein-Coupled genetics
Tumor Necrosis Factor-alpha pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3468
- Volume :
- 586
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 22245676
- Full Text :
- https://doi.org/10.1016/j.febslet.2012.01.001