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Relationship between CRP polymorphism and cardiovascular events in Chinese peritoneal dialysis patients.
- Source :
-
Clinical journal of the American Society of Nephrology : CJASN [Clin J Am Soc Nephrol] 2012 Feb; Vol. 7 (2), pp. 304-9. Date of Electronic Publication: 2012 Jan 12. - Publication Year :
- 2012
-
Abstract
- Background and Objectives: The single-nucleotide polymorphism (SNP) -717A→G substitution, rs2794521, was found in the promoter of the C-reactive protein (CRP) gene. Functional studies showed that A allele promoter has higher transcriptional activity than the G allele. This study investigated the association between this SNP and the outcome of Chinese patients undergoing peritoneal dialysis (PD).<br />Design, Setting, Participants, & Measurements: The study included 441 new PD patients (232 men; mean age ± SD, 56.7±13.5 years). CRP genotyping was determined; patients were followed for 41.3±18.3 months for cardiovascular events.<br />Results: For the entire cohort, 5-year event-free survival rates did not differ between the AA and AG/GG groups (35.7% and 31.9%, respectively; P=0.64). However, there was significant interaction between plasma cholesterol levels and CRP genotype groups on event-free survival (P=0.04 for interaction). For patients with cholesterol levels of 200 mg/dl or greater, the 5-year event-free survival rate in the AG/GG group was significantly better than that in the AA group (54.7% versus 40.0%; P=0.04), whereas there was no difference in event-free survival between genotype groups for patients with cholesterol levels less than 200 mg/dl.<br />Conclusions: CRP gene -717AG or GG genotypes is associated with cardiovascular benefit to Chinese PD patients with cholesterol levels of 200 mg/dl or greater. These findings suggest a complex interaction among cholesterol, CRP, and cardiovascular disease in PD patients.
- Subjects :
- Adult
Aged
Analysis of Variance
Cardiovascular Diseases blood
Cardiovascular Diseases mortality
Chi-Square Distribution
China epidemiology
Cholesterol blood
Disease-Free Survival
Female
Genotype
Humans
Kaplan-Meier Estimate
Kidney Diseases blood
Kidney Diseases complications
Kidney Diseases ethnology
Kidney Diseases genetics
Kidney Diseases mortality
Male
Middle Aged
Peritoneal Dialysis mortality
Phenotype
Proportional Hazards Models
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Asian People genetics
C-Reactive Protein genetics
Cardiovascular Diseases genetics
Kidney Diseases therapy
Peritoneal Dialysis adverse effects
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1555-905X
- Volume :
- 7
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical journal of the American Society of Nephrology : CJASN
- Publication Type :
- Academic Journal
- Accession number :
- 22241816
- Full Text :
- https://doi.org/10.2215/CJN.04470511