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[Metabotropic glutamate receptors as targets for new drug development].
- Source :
-
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2011; Vol. 74 (10), pp. 46-52. - Publication Year :
- 2011
-
Abstract
- The review is devoted to experimental investigations of metabotropic glutamate receptors and the properties of drugs (ligands) belonging to agonists, antagonists, and modulators of the activity of these receptors. Possibilities of the treatment of neurodegenerative disorders, cognitive disturbances in schizophrenia patients, and narcotic dependency by using drugs of this class are considered.
- Subjects :
- Animals
Cognition Disorders metabolism
Cognition Disorders physiopathology
Excitatory Amino Acid Agonists administration & dosage
Excitatory Amino Acid Antagonists administration & dosage
Humans
Ligands
Neurodegenerative Diseases metabolism
Neurodegenerative Diseases physiopathology
Schizophrenia metabolism
Schizophrenia physiopathology
Cognition Disorders drug therapy
Excitatory Amino Acid Agonists therapeutic use
Excitatory Amino Acid Antagonists therapeutic use
Neurodegenerative Diseases drug therapy
Receptors, Metabotropic Glutamate agonists
Receptors, Metabotropic Glutamate antagonists & inhibitors
Receptors, Metabotropic Glutamate metabolism
Schizophrenia drug therapy
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-2092
- Volume :
- 74
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Eksperimental'naia i klinicheskaia farmakologiia
- Publication Type :
- Academic Journal
- Accession number :
- 22238988