Back to Search
Start Over
Scheduled prospective tri-weekly modified FOLFOX6 maintenance chemotherapy in the treatment of metastatic colorectal cancer.
- Source :
-
Hepato-gastroenterology [Hepatogastroenterology] 2011 Nov-Dec; Vol. 58 (112), pp. 1930-2. - Publication Year :
- 2011
-
Abstract
- Background/aims: Oxaliplatin, which is effective for colorectal cancer (CRC) in combination with 5-fluorouracil (5-FU) and leucovorin (LV), is widely used for metastatic CRC. With the increasing use of oxaliplatin, however, serious adverse events have been experienced, including hematologic and neurologic toxicities. The aim of this study was to evaluate whether tri-weekly modified FOLFOX6 (mFOLFOX6) maintenance chemotherapy is associated with a low incidence of severe hematologic and neurologic toxicities in the treatment of patients with metastatic CRC.<br />Methodology: We developed a new treatment regimen with mFOLFOX6 biweekly for 8-10 consecutive cycles (induction phase) followed by a 3-week rest period, after which treatment was resumed with cycles of tri-weekly mFOLFOX6 at standard doses (maintenance phase). Validity and complications were investigated retrospectively.<br />Results: Twenty-nine patients were enrolled in this study. The median progression-free survival (PFS) and overall survival (OS) times were 9.4 months and 23 months, respectively. All patients had peripheral neuropathy during treatment, but grade 3 neurotoxicity was observed in only 2 patients (6.9%).<br />Conclusions: mFOLFOX6 maintenance chemotherapy was associated with a very low incidence of grade 3 hematologic and neurologic toxicities. The toxicities associated with PFS and OS were comparable to those reported in the treatment of patients with metastatic CRC. A tri-weekly mFOLFOX maintenance strategy of alternative treatment with a less-toxic regimen may reduce toxicity and maintain efficacy.
- Subjects :
- Adult
Aged
Antineoplastic Combined Chemotherapy Protocols adverse effects
Colonic Neoplasms pathology
Drug Administration Schedule
Female
Fluorouracil administration & dosage
Fluorouracil adverse effects
Humans
Leucovorin administration & dosage
Leucovorin adverse effects
Male
Middle Aged
Neoplasm Metastasis
Organoplatinum Compounds administration & dosage
Organoplatinum Compounds adverse effects
Retrospective Studies
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Colonic Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0172-6390
- Volume :
- 58
- Issue :
- 112
- Database :
- MEDLINE
- Journal :
- Hepato-gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 22234064
- Full Text :
- https://doi.org/10.5754/hge10110