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Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: results from the DIAD study.
- Source :
-
Diabetes & vascular disease research [Diab Vasc Dis Res] 2012 Apr; Vol. 9 (2), pp. 124-30. Date of Electronic Publication: 2012 Jan 06. - Publication Year :
- 2012
-
Abstract
- Gender differences in cardiovascular outcomes were compared in asymptomatic men and women with type 2 diabetes (T2DM) in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study. Of 1123 participants, 290 men and 271 women were randomised to screening with stress myocardial perfusion imaging (MPI); 311 men and 251 women were randomised to no screening. Follow-up was 4.8±0.9 years for the occurrence of cardiac events (CE; cardiac death or non-fatal myocardial infarction). The frequency of abnormal screening was similar in men (24%) and women (19%), (p=0.2), although women trended to have smaller MPI abnormalities. CE rates were lower in women than men (1.7% vs. 3.8%, p=0.04). No CEs occurred in 17 high-risk (UKPDS risk engine) women, whereas 14 (11.2%) occurred in 125 high-risk men. Asymptomatic women with T2DM have significantly better cardiac outcomes than their male counterparts and represent a subgroup for which screening for coronary artery disease does not appear warranted.
- Subjects :
- Aged
Asymptomatic Diseases
Canada epidemiology
Cardiovascular Diseases diagnosis
Cardiovascular Diseases mortality
Diabetes Complications diagnosis
Diabetes Complications mortality
Diabetes Mellitus, Type 2 mortality
Female
Humans
Incidence
Kaplan-Meier Estimate
Male
Mass Screening methods
Middle Aged
Myocardial Perfusion Imaging
Predictive Value of Tests
Prognosis
Prospective Studies
Risk Assessment
Risk Factors
Sex Factors
Time Factors
United States epidemiology
Cardiovascular Diseases epidemiology
Diabetes Complications epidemiology
Diabetes Mellitus, Type 2 epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1752-8984
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Diabetes & vascular disease research
- Publication Type :
- Academic Journal
- Accession number :
- 22228772
- Full Text :
- https://doi.org/10.1177/1479164111431470