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Potential implications of coronary artery calcium testing for guiding aspirin use among asymptomatic individuals with diabetes.
- Source :
-
Diabetes care [Diabetes Care] 2012 Mar; Vol. 35 (3), pp. 624-6. Date of Electronic Publication: 2012 Jan 06. - Publication Year :
- 2012
-
Abstract
- Objective: It is unclear whether coronary artery calcium (CAC) is effective for risk stratifying patients with diabetes in whom treatment decisions are uncertain.<br />Research Design and Methods: Of 44,052 asymptomatic individuals referred for CAC testing, we studied 2,384 individuals with diabetes. Subjects were followed for a mean of 5.6 ± 2.6 years for the end point of all-cause mortality.<br />Results: There were 162 deaths (6.8%) in the population. CAC was a strong predictor of mortality across age-groups (age <50, 50-59, ≥60), sex, and risk factor burden (0 vs. ≥1 additional risk factor). In individuals without a clear indication for aspirin per current guidelines, CAC stratified risk, identifying patients above and below the 10% risk threshold of presumed aspirin benefit.<br />Conclusions: CAC can help risk stratify individuals with diabetes and may aid in selection of patients who may benefit from therapies such as low-dose aspirin for primary prevention.
Details
- Language :
- English
- ISSN :
- 1935-5548
- Volume :
- 35
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Diabetes care
- Publication Type :
- Academic Journal
- Accession number :
- 22228745
- Full Text :
- https://doi.org/10.2337/dc11-1773