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Hospitalizations for intussusception before and after the reintroduction of rotavirus vaccine in the United States.
- Source :
-
Archives of pediatrics & adolescent medicine [Arch Pediatr Adolesc Med] 2012 Apr; Vol. 166 (4), pp. 350-5. Date of Electronic Publication: 2012 Jan 02. - Publication Year :
- 2012
-
Abstract
- Objective: To determine whether hospital discharges for intussusception in children younger than 1 year have changed since the reintroduction of rotavirus vaccine in the United States.<br />Design: Serial cross-sectional analysis.<br />Setting: US hospitals.<br />Participants: Children younger than 1 year with a discharge diagnosis of intussusception identified in the Kids' Inpatient Database, a series of nationally representative data sets of pediatric hospital discharges in the United States with 4 available years prior to vaccine reintroduction (1997, 2000, 2003, and 2006) and 1 year after (2009).<br />Main Exposures: Hospital discharge before vs after rotavirus vaccine reintroduction.<br />Outcome Measures: Total number and rate of hospital discharges for infants younger than 1 year with a diagnosis of intussusception (International Classification of Diseases, Ninth Revision, Clinical Modification code 560.0).<br />Results: From 1997 to 2006, there was no change in the total number of hospital discharges for intussusception, with a small decrease in the rate of intussusception discharges (41.6 [95% CI, 36.7-46.5] to 36.5 [95% CI, 31.7-41.2] per 100,000 infants). Based on the trend, the predicted rate of discharges for intussusception in 2009 was 36.0 (95% CI, 30.2-41.8) per 100,000 infants. The measured rate of hospital discharges for intussusception in 2009 was 33.3 (95% CI, 29.0-37.6) per 100,000 infants.<br />Conclusion: The reintroduction of rotavirus vaccine since 2006 has not resulted in a detectable increase in the number of hospital discharges for intussusception among US infants.
- Subjects :
- Adverse Drug Reaction Reporting Systems
Cross-Sectional Studies
Female
Humans
Incidence
Infant
Infant, Newborn
Intussusception etiology
Male
Retreatment
Retrospective Studies
United States epidemiology
Hospitalization trends
Inpatients statistics & numerical data
Intussusception epidemiology
Rotavirus Infections prevention & control
Rotavirus Vaccines adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1538-3628
- Volume :
- 166
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Archives of pediatrics & adolescent medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22213609
- Full Text :
- https://doi.org/10.1001/archpediatrics.2011.1501