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Analysis of failures in patients with FIGO stage IIIc1-IIIc2 endometrial cancer.
- Source :
-
Anticancer research [Anticancer Res] 2012 Jan; Vol. 32 (1), pp. 201-5. - Publication Year :
- 2012
-
Abstract
- Aim: To assess the pattern of failures in patients with FIGO stage IIIc(1)-IIIc(2) endometrial cancer.<br />Patients and Methods: Data were retrospectively analyzed for 34 patients with this malignancy who underwent extra-fascial total hysterectomy, bilateral salpingo-oophorectomy and pelvic/para-aortic node dissection. Postoperative treatment consisted of radiotherapy in 5 patients, 6 cycles of chemotherapy in 9, and 3-4 cycles of chemotherapy followed by radiotherapy in 20. The median follow-up of survivors was 33 months (range, 6 to 133 months).<br />Results: Tumour relapsed in 14 out of 34 patients (41.2%). Median time to recurrence was 17 months (range, 9.5-42 months). Vaginal recurrence developed in 2 patients (5.9%), distant recurrence in 5 (14.7%), pelvic node recurrence in 3 (8.8%) and para-aortic recurrence in 7 (20.6%). Two patients had multiple sites of recurrence. Distant failure occurred in 11.1% of the patients who received 6 cycles of chemotherapy versus 20.0% of those who had 3-4 cycles of chemotherapy followed by radiotherapy. Five-year overall survival was 60.5%, and, in particular, it was 62.5% for stage IIIc(1) and 57.0% for stage IIIc(2).<br />Conclusion: FIGO stage IIIc(1)-IIIc(2) endometrial cancer relapses in approximately 40% of cases, and distant sites and para-aortic nodes represent the most common sites of failure.
- Subjects :
- Adult
Aged
Chemotherapy, Adjuvant
Combined Modality Therapy
Endometrial Neoplasms pathology
Female
Follow-Up Studies
Humans
Hysterectomy
Lymph Node Excision
Lymphatic Metastasis
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local mortality
Neoplasm Recurrence, Local pathology
Neoplasm Staging
Ovariectomy
Pelvic Neoplasms secondary
Radiotherapy, Adjuvant
Retrospective Studies
Survival Rate
Treatment Failure
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Endometrial Neoplasms mortality
Endometrial Neoplasms therapy
Neoplasm Recurrence, Local therapy
Pelvic Neoplasms mortality
Pelvic Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 32
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 22213308