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Roles of Apicomplexan protein kinases at each life cycle stage.
- Source :
-
Parasitology international [Parasitol Int] 2012 Jun; Vol. 61 (2), pp. 224-34. Date of Electronic Publication: 2011 Dec 24. - Publication Year :
- 2012
-
Abstract
- Inhibitors of cellular protein kinases have been reported to inhibit the development of Apicomplexan parasites, suggesting that the functions of protozoan protein kinases are critical for their life cycle. However, the specific roles of these protein kinases cannot be determined using only these inhibitors without molecular analysis, including gene disruption. In this report, we describe the functions of Apicomplexan protein kinases in each parasite life stage and the potential of pre-existing protein kinase inhibitors as Apicomplexan drugs against, mainly, Plasmodium and Toxoplasma.<br /> (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Animals
Apicomplexa drug effects
Apicomplexa genetics
Apicomplexa growth & development
Plasmodium drug effects
Plasmodium enzymology
Plasmodium genetics
Plasmodium growth & development
Protein Kinases drug effects
Protein Kinases genetics
Protozoan Proteins drug effects
Protozoan Proteins genetics
Toxoplasma drug effects
Toxoplasma enzymology
Toxoplasma genetics
Toxoplasma growth & development
Apicomplexa enzymology
Life Cycle Stages
Protein Kinase Inhibitors pharmacology
Protein Kinases metabolism
Protozoan Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-0329
- Volume :
- 61
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Parasitology international
- Publication Type :
- Academic Journal
- Accession number :
- 22209882
- Full Text :
- https://doi.org/10.1016/j.parint.2011.12.002