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[Three cases of hepatocellular carcinoma without distant metastasis effectively treated by sorafenib].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2011 Nov; Vol. 38 (12), pp. 2496-8. - Publication Year :
- 2011
-
Abstract
- Sorafenib is a novel, orally administered multi-kinase inhibitor that has recently been approved for the treatment of advanced hepatocellular carcinoma. We report three cases of hepatocellular carcinoma without distant metastasis effectively treated by sorafenib. Case 1 was a 71-year-old male with multiple hepatocellular carcinomas, Child-Pugh status A, and asthma. He received sorafenib 400 mg twice daily. The efficacy evaluated by the RECIST was partial response. Case 2 was a 75-year-old male with multiple hepatocellular carcinomas and Child-Pugh status A. He previously received surgical resection and transarterial chemoembolization. He received sorafenib 400 mg twice daily. The efficacy evaluated by the RECIST and modified RECIST was partial response and complete response, respectively. Case 3 was a 62-year-old male with multiple hepatocellular carcinomas and Child-Pugh status A. He previously received surgical resection, percutaneous radiofrequency ablation therapy and transarterial chemoembolization. He received sorafenib 400 mg twice daily. The efficacy evaluated by the RECIST was stable disease. The majority of adverse events were grade 1-2 stomatitis and hand-foot skin reaction. No patients discontinued the treatment because of adverse events. Sorafenib might be promising as an effective therapy for advanced hepatocellular carcinoma without distant metastasis.
- Subjects :
- Aged
Carcinoma, Hepatocellular pathology
Humans
Liver Neoplasms pathology
Male
Middle Aged
Neoplasm Metastasis
Niacinamide analogs & derivatives
Phenylurea Compounds
Sorafenib
Tomography, X-Ray Computed
Antineoplastic Agents therapeutic use
Benzenesulfonates therapeutic use
Carcinoma, Hepatocellular drug therapy
Liver Neoplasms drug therapy
Protein Kinase Inhibitors therapeutic use
Pyridines therapeutic use
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 38
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 22202425