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[Curative resection for bulky gastrointestinal stromal tumor with conversion therapy by imatinib].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2011 Nov; Vol. 38 (12), pp. 2202-4. - Publication Year :
- 2011
-
Abstract
- Imatinib is a standard treatment for unresectable gastrointestinal stromal tumor (GIST). We described the case of a 66- year-old woman with bulky GIST of which a diameter was 25 cm. Therefore, we decided the tumor was unresectable. After 2-year administration of imatinib, the diameter of tumor was reduced to 6 cm. After 3-year administration of imatinib, the diameter of tumor was increased to 8 cm. The patient did not have any distant metastasis. He underwent a resection of the tumor. The historical examination showed that c-kit and CD34 were positive. The number of mitosis was 12/50 HPF. Conversion chemotherapy for bulky GIST may contribute to a curative resection.
- Subjects :
- Aged
Benzamides
Combined Modality Therapy
Female
Gastrointestinal Neoplasms pathology
Gastrointestinal Neoplasms surgery
Gastrointestinal Stromal Tumors pathology
Gastrointestinal Stromal Tumors surgery
Humans
Imatinib Mesylate
Antineoplastic Agents therapeutic use
Gastrointestinal Neoplasms drug therapy
Gastrointestinal Stromal Tumors drug therapy
Piperazines therapeutic use
Pyrimidines therapeutic use
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 38
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 22202330