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Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: report of a case.
- Source :
-
Surgery today [Surg Today] 2012 Jan; Vol. 42 (2), pp. 181-4. Date of Electronic Publication: 2011 Dec 27. - Publication Year :
- 2012
-
Abstract
- Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by progressive heart failure, and is a leading cause of mortality and morbidity. Recently, cellular therapy for end-stage heart failure has been emerging. We herein report a 56-year-old male who received a transplant of autologous myoblast sheets manufactured in temperature-responsive culture dishes. His clinical condition improved markedly, leaving him without any arrhythmia and able to discontinue using a left ventricular assist system and avoid cardiac transplantation. These findings suggest that cellular therapy using myoblast sheets is a promising new strategy for treating patients with end-stage DCM. This method might be an effective alternative to heart transplantation in the near future.
- Subjects :
- Cardiomyopathy, Dilated physiopathology
Cells, Cultured
Follow-Up Studies
Humans
Male
Middle Aged
Transplantation, Autologous
Cardiomyopathy, Dilated therapy
Cell Transplantation instrumentation
Heart-Assist Devices
Myoblasts, Skeletal transplantation
Stroke Volume physiology
Tissue Engineering
Ventricular Function physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1436-2813
- Volume :
- 42
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Surgery today
- Publication Type :
- Academic Journal
- Accession number :
- 22200756
- Full Text :
- https://doi.org/10.1007/s00595-011-0106-4