Back to Search
Start Over
Short telomere length, myocardial infarction, ischemic heart disease, and early death.
- Source :
-
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2012 Mar; Vol. 32 (3), pp. 822-9. Date of Electronic Publication: 2011 Dec 22. - Publication Year :
- 2012
-
Abstract
- Objective: We tested the hypothesis that short telomere length is associated with increased risk of myocardial infarction, ischemic heart disease, and early death.<br />Methods and Results: We measured leukocyte telomere length in 2 prospective studies of 19 838 Danish general population participants from the Copenhagen City Heart Study and the Copenhagen General Population Study. Participants were followed for up to 19 years for incident myocardial infarction (n=929), ischemic heart disease (n=2038), and death (n=4342). Follow-up was 100% complete. Telomere length decreased linearly with increasing age in women and men in both studies (P=7×10(-74) to P=3×10(-125)). Multifactorially adjusted hazard ratios were 1.10 (95% CI 1.01-1.19) for myocardial infarction, 1.06 (1.00-1.11) for ischemic heart disease, and 1.09 (1.05-1.13) for early death per 1000-base pair decrease in telomere length. The multifactorially adjusted hazard ratios for the shortest versus the longest decile of telomere length were 1.49 (1.07-2.07) for myocardial infarction, 1.24 (1.01-1.53) for ischemic heart disease, and 1.25 (1.07-1.46) for early death.<br />Conclusion: Short telomere length is associated with only modestly increased risk of myocardial infarction, ischemic heart disease, and early death.
- Subjects :
- Adult
Age Factors
Aged
Aging genetics
Denmark epidemiology
Female
Follow-Up Studies
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Phenotype
Proportional Hazards Models
Prospective Studies
Real-Time Polymerase Chain Reaction
Risk Assessment
Risk Factors
Time Factors
Myocardial Infarction genetics
Myocardial Infarction mortality
Myocardial Ischemia genetics
Myocardial Ischemia mortality
Telomere Shortening
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4636
- Volume :
- 32
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Arteriosclerosis, thrombosis, and vascular biology
- Publication Type :
- Academic Journal
- Accession number :
- 22199369
- Full Text :
- https://doi.org/10.1161/ATVBAHA.111.237271