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Expressions of MAGE-A10 and MAGE-A11 in breast cancers and their prognostic significance: a retrospective clinical study.

Authors :
Lian Y
Sang M
Ding C
Zhou X
Fan X
Xu Y
Lü W
Shan B
Source :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2012 Mar; Vol. 138 (3), pp. 519-27. Date of Electronic Publication: 2011 Dec 25.
Publication Year :
2012

Abstract

Purpose: Melanoma-associated antigens-A (MAGE-A) family is a group of well-characterized cancer/testis antigens (CTA), because they are strictly tumor specific and are shared by many kinds of tumors. However, the expression pattern of MAGE-A10 and MAGE-A11 in breast cancer patients is still unclear. The purpose of our study is to investigate the expression pattern and prognostic significance of MAGE-A10 and MAGE-A11 in breast cancer patients.<br />Methods: Formalin-fixed and paraffin-embedded tissues and the clinicopathological parameters from 75 primary breast cancer patients were collected. The expressions of MAGE-A10 and MAGE-A11 proteins were immunohistochemically detected, and the association of MAGE-A10 and MAGE-A11 expressions with the clinicopathological parameters and the survival of breast cancer patients were analyzed.<br />Results: The expression rates of MAGE-A10 and MAGE-A11 in breast cancer specimens were 73.3 and 52.0%, respectively. MAGE-A11 expression was more frequent in estrogen-receptor (ER)-positive breast carcinomas compared with ER-negative breast carcinomas (P = 0.004). MAGE-A11 expression was positively associated with HER-2 expression (P = 0.003). Overall survival of patients with MAGE-A11-negative expression was significantly longer than those patients with positive MAGE-A11 expression (P = 0.030), but no difference of overall survival was found between patients with MAGE-A10-negative and -positive expression (P = 0.881).<br />Conclusions: MAGE-A10 and MAGE-A11 are tumor-specific antigens, and MAGE-A11 expression probably is a potential poor prognostic factor for breast cancer patients.

Details

Language :
English
ISSN :
1432-1335
Volume :
138
Issue :
3
Database :
MEDLINE
Journal :
Journal of cancer research and clinical oncology
Publication Type :
Academic Journal
Accession number :
22198676
Full Text :
https://doi.org/10.1007/s00432-011-1122-x