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Uniform mesoporous carbon as a carrier for poorly water soluble drug and its cytotoxicity study.
- Source :
-
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2012 Apr; Vol. 80 (3), pp. 535-43. Date of Electronic Publication: 2011 Dec 13. - Publication Year :
- 2012
-
Abstract
- In this study, uniform mesoporous carbon spheres (UMCS) with 3-D pore system and fibrous ordered mesoporous carbon (FOMC) with 2-dimensional hexagonal mesoporous structure were studied as drug carriers for oral drug delivery system. Lovastatin (LOV), which has low water solubility, was chosen as a model drug. Drug release rate and degree of drug loading of UMCS and FOMC were compared. The effects of different pore channel structures and pore sizes on LOV uptake and release were systematically investigated. Cytotoxicity of UMCS and FOMC on human colon carcinoma (Caco-2) cells were also studied. The results indicate that UMCS has a higher degree of drug loading (up to 36.26% drug weight/total weight) compared with FOMC. The dissolution rate of LOV from UMCS was found to be markedly increased compared with pure crystalline LOV, and the dissolution rate of LOV from FOMC was relatively sustained compared with UMCS, and both UMCS and FOMC exhibited a weak cytotoxicity at tested concentrations (10-800 μg/ml).<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Subjects :
- Biological Availability
Caco-2 Cells
Carbon Fiber
Cell Line, Tumor
Drug Delivery Systems methods
Humans
Microscopy, Electron, Transmission methods
Nanoparticles chemistry
Nanostructures chemistry
Particle Size
Porosity
Solubility
Water chemistry
Carbon chemistry
Drug Carriers chemistry
Lovastatin chemistry
Lovastatin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3441
- Volume :
- 80
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
- Publication Type :
- Academic Journal
- Accession number :
- 22193360
- Full Text :
- https://doi.org/10.1016/j.ejpb.2011.12.002