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Cyto-mechanoresponsive polyelectrolyte multilayer films.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2012 Jan 11; Vol. 134 (1), pp. 83-6. Date of Electronic Publication: 2011 Dec 20. - Publication Year :
- 2012
-
Abstract
- Cell adhesion processes take place through mechanotransduction mechanisms where stretching of proteins results in biological responses. In this work, we present the first cyto-mechanoresponsive surface that mimics such behavior by becoming cell-adhesive through exhibition of arginine-glycine-aspartic acid (RGD) adhesion peptides under stretching. This mechanoresponsive surface is based on polyelectrolyte multilayer films built on a silicone sheet and where RGD-grafted polyelectrolytes are embedded under antifouling phosphorylcholine-grafted polyelectrolytes. The stretching of this film induces an increase in fibroblast cell viability and adhesion.<br /> (© 2011 American Chemical Society)
Details
- Language :
- English
- ISSN :
- 1520-5126
- Volume :
- 134
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 22188330
- Full Text :
- https://doi.org/10.1021/ja208970b