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Pro-inflammatory functions of carp CXCL8-like and CXCb chemokines.
- Source :
-
Developmental and comparative immunology [Dev Comp Immunol] 2012 Apr; Vol. 36 (4), pp. 741-50. Date of Electronic Publication: 2011 Dec 09. - Publication Year :
- 2012
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Abstract
- Numerous CXC chemokines have been identified in fish, however, their role in inflammation is not well established. Here, CXC chemokines of the CXCL8-like (CXCa&#95;L1 and CXCL8&#95;L2) and CXCL9/10/11-like (CXCb) subset were investigated in carp. Recombinant CXCa&#95;L1, CXCL8&#95;L2 and CXCb all stimulated chemotaxis of macrophages and granulocytes in vitro. CXCb also attracted lymphocytes. Distinct effects on phagocyte activation were observed: the CXCL8-like chemokines increase respiratory burst activity, but not nitrite production. The three chemokines differentially induced a moderate increase in IL-1β, CXCa&#95;L1 and CXCL8&#95;L2 gene expression. Intracellular calcium mobilization in granulocytes upon CXCa&#95;L1 stimulation implies signal transduction through G-protein coupled CXC receptors. Notably, upon intraperitoneal administration, carp CXCL8-like chemokines strongly induced in vivo leukocyte recruitment, including neutrophils and monocytes/macrophages, in contrast to CXCb, for which the number of recruited leukocytes was low. The results indicate functional homology for carp CXCL8-like and CXCb chemokines with mammalian CXCL8 and CXCL9-11, respectively.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0089
- Volume :
- 36
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Developmental and comparative immunology
- Publication Type :
- Academic Journal
- Accession number :
- 22182503
- Full Text :
- https://doi.org/10.1016/j.dci.2011.11.011