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Endometriosis-associated nerve fibers, peritoneal fluid cytokine concentrations, and pain in endometriotic lesions from different locations.
- Source :
-
Fertility and sterility [Fertil Steril] 2012 Feb; Vol. 97 (2), pp. 373-80. Date of Electronic Publication: 2011 Dec 10. - Publication Year :
- 2012
-
Abstract
- Objective: To assess the relationship between endometriotic lesions with associated nerve fibers with both pain and peritoneal fluid (PF) cytokine concentrations based on lesion location.<br />Design: An observational study.<br />Setting: University hospital.<br />Patient(s): Premenopausal women undergoing laparoscopy.<br />Intervention(s): The pain experienced by patients was recorded before surgery and ectopic endometrial tissue excised and matching PF collected during laparoscopy. Immunohistochemistry was performed on endometriotic tissue sections to identify nerve fibers and PF cytokine concentrations determined.<br />Main Outcome Measure(s): The pain experienced by women with endometriosis, the lesion locations, and the prevalence and proximity of nerve fibers to endometriotic lesions, as well as the PF concentrations of multiple cytokines.<br />Result(s): Lesions from the rectovaginal septum were significantly more likely to be associated with a nerve fiber and report more menstrual pain than lesions from other regions. The PF glycodelin concentrations were also significantly higher in samples with an endometriotic-associated nerve. In peritoneal endometriotic lesions significantly more menstrual pain was reported when endometriotic lesions were associated with nerve fibers, although no difference was observed between the cytokine concentrations. Ovarian endometriotic lesions were rarely associated with nerve fibers.<br />Conclusion(s): The presence of endometriosis-associated nerve fibers appear to be related to both the pain experienced by women with endometriosis and the concentration of PF cytokines; however, this association varies with the lesion location.<br /> (Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Analysis of Variance
Ascitic Fluid immunology
Biomarkers analysis
Endometriosis immunology
Endometriosis pathology
Endometriosis surgery
Enzyme-Linked Immunosorbent Assay
Female
Hospitals, University
Humans
Immunohistochemistry
Laparoscopy
Nerve Fibers chemistry
Ovarian Diseases immunology
Ovarian Diseases pathology
Ovarian Diseases surgery
Pain Measurement
Pelvic Pain immunology
Pelvic Pain pathology
Peritoneal Diseases immunology
Peritoneal Diseases pathology
Peritoneal Diseases surgery
Radioimmunoassay
Rectal Diseases immunology
Rectal Diseases pathology
Rectal Diseases surgery
Switzerland
Ubiquitin Thiolesterase analysis
Vaginal Diseases immunology
Vaginal Diseases pathology
Vaginal Diseases surgery
Cytokines analysis
Endometriosis complications
Nerve Fibers pathology
Ovarian Diseases complications
Pelvic Pain etiology
Peritoneal Diseases complications
Rectal Diseases complications
Vaginal Diseases complications
Subjects
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 97
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 22154765
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2011.11.011