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Novel poly(ADP-ribose) polymerase-1 inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Jan 01; Vol. 22 (1), pp. 222-4. Date of Electronic Publication: 2011 Nov 17. - Publication Year :
- 2012
-
Abstract
- Synthesis and activity of a series of 3-aroyl-derived analogs of novel pyrrolocarbazole 1 as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors are disclosed.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Carbazoles chemistry
Chemistry, Pharmaceutical methods
DNA Damage
Drug Design
Humans
Inhibitory Concentration 50
Models, Chemical
NAD chemistry
Neoplasms drug therapy
PC12 Cells
Poly (ADP-Ribose) Polymerase-1
Rats
Enzyme Inhibitors pharmacology
Poly(ADP-ribose) Polymerase Inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 22153339
- Full Text :
- https://doi.org/10.1016/j.bmcl.2011.11.032