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The AKT1 gene is associated with attention and brain morphology in schizophrenia.
- Source :
-
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2013 Mar; Vol. 14 (2), pp. 100-13. Date of Electronic Publication: 2011 Dec 12. - Publication Year :
- 2013
-
Abstract
- Objectives: A meta-analysis of the associations between genetic variants in the AKT1 gene and schizophrenia found that a single nucleotide polymorphism (SNP5; rs2494732) was associated with schizophrenia in Asian populations.<br />Methods: In this study, we investigated the effects of this SNP on memory and attentional performance and brain structure using magnetic resonance imaging in a Japanese population (117 patients with schizophrenia and 189 healthy subjects).<br />Results: The memory performance, particularly attention/concentration score, measured by the Wechsler Memory Scale-Revised in A carriers of SNP5, which was found to be enriched in patients with schizophrenia, was lower than that in individuals with the G/G genotype. We confirmed the association of the SNP with attentional performance using the Continuous Performance Test, which assessed sustained attention and vigilance of attentional function. Patients with A allele demonstrated lower attentional performance than patients with the G/G genotype. Patients with the A allele had smaller gray matter volumes in the right inferior parietal lobule related to attentional processes and in the frontostriatal region related to different SNPs in AKT1 than patients with the G/G genotype.<br />Conclusions: Our results suggest that a genetic variant of AKT1 might be associated with attentional deficits and brain morphological vulnerability in patients with schizophrenia.
- Subjects :
- Adult
Brain metabolism
Brain pathology
Female
Genetic Predisposition to Disease
Humans
Japan
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Organ Size genetics
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-akt metabolism
Psychiatric Status Rating Scales
Schizophrenia pathology
Schizophrenic Psychology
Attention physiology
Memory physiology
Proto-Oncogene Proteins c-akt genetics
Schizophrenia genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1814-1412
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 22150081
- Full Text :
- https://doi.org/10.3109/15622975.2011.591826