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Age dependent expression of melatonin membrane receptor (MT1, MT2) and its role in regulation of nitrosative stress in tropical rodent Funambulus pennanti.
- Source :
-
Free radical research [Free Radic Res] 2012 Feb; Vol. 46 (2), pp. 194-203. Date of Electronic Publication: 2012 Jan 23. - Publication Year :
- 2012
-
Abstract
- Age-dependent declining level of melatonin induces free radical load and thereby deteriorates immune function. However, reports are lacking about age-dependent melatonin membrane receptor (MT1 & MT2) expression, their role in regulation of reactive nitrogen species (RNS) and eventually how they affect immunity of a tropical rodent F. pennanti. We checked MT1R, MT2R and iNOS expression in lymphoid organs of young middle and old aged squirrels. Nitrite and nitrate ion concentration (NOx) in lymphoid organs, testes and plasma, lymphocyte proliferation and IL-2 level was recorded. Age-dependent decrease in MT1 and MT2 receptor expression, lymphocyte proliferation, IL-2 level and increased RNS in lymphoid organs, testes and plasma was observed with decreased circulatory melatonin. Androgen and AR expression was increased in middle-aged while declined in old-aged squirrels. Present study suggests that age associated immunosenescence is consequence of increased RNS which might have important relationship with melatonin membrane receptors in F. pennanti.
- Subjects :
- Age Factors
Animals
Cell Proliferation
Cells, Cultured
Gene Expression
Interleukin-2 blood
Interleukin-2 metabolism
Lymphocyte Activation
Lymphocytes metabolism
Lymphocytes physiology
Male
Melatonin blood
Melatonin metabolism
Nitric Oxide Synthase Type II genetics
Nitric Oxide Synthase Type II metabolism
Reactive Nitrogen Species blood
Receptor, Melatonin, MT1 genetics
Receptor, Melatonin, MT1 metabolism
Receptor, Melatonin, MT2 genetics
Receptor, Melatonin, MT2 metabolism
Receptors, Androgen metabolism
Sciuridae metabolism
Spleen cytology
Spleen enzymology
Spleen metabolism
Testis enzymology
Testis metabolism
Testosterone blood
Thymus Gland cytology
Thymus Gland enzymology
Thymus Gland metabolism
Gene Expression Regulation
Reactive Nitrogen Species metabolism
Receptor, Melatonin, MT1 physiology
Receptor, Melatonin, MT2 physiology
Sciuridae physiology
Stress, Physiological
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2470
- Volume :
- 46
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Free radical research
- Publication Type :
- Academic Journal
- Accession number :
- 22149391
- Full Text :
- https://doi.org/10.3109/10715762.2011.647690