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Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer.
- Source :
-
Cancer investigation [Cancer Invest] 2012 Feb; Vol. 30 (2), pp. 92-7. Date of Electronic Publication: 2011 Dec 07. - Publication Year :
- 2012
-
Abstract
- Global histone modification patterns have been shown to be a predictive factor of recurrence in various cancers. We analyzed global histone-3-lysine-27 (H3K27) methylation in prostate cancer (PCA) tissues. H3K27 mono-, di-, and tri-methylation patterns were different in nonmalignant prostate tissue, localized PCA, metastatic PCA, and castration-resistant PCA. H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis.
Details
- Language :
- English
- ISSN :
- 1532-4192
- Volume :
- 30
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer investigation
- Publication Type :
- Academic Journal
- Accession number :
- 22149091
- Full Text :
- https://doi.org/10.3109/07357907.2011.636117