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Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: design and implementation of the CORE320 multicenter, multinational diagnostic study.
- Source :
-
Journal of cardiovascular computed tomography [J Cardiovasc Comput Tomogr] 2011 Nov-Dec; Vol. 5 (6), pp. 370-81. Date of Electronic Publication: 2011 Nov 12. - Publication Year :
- 2011
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Abstract
- Multidetector coronary computed tomography angiography (CTA) is a promising modality for widespread clinical application because of its noninvasive nature and high diagnostic accuracy as found in previous studies using 64 to 320 simultaneous detector rows. It is, however, limited in its ability to detect myocardial ischemia. In this article, we describe the design of the CORE320 study ("Combined coronary atherosclerosis and myocardial perfusion evaluation using 320 detector row computed tomography"). This prospective, multicenter, multinational study is unique in that it is designed to assess the diagnostic performance of combined 320-row CTA and myocardial CT perfusion imaging (CTP) in comparison with the combination of invasive coronary angiography and single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI). The trial is being performed at 16 medical centers located in 8 countries worldwide. CT has the potential to assess both anatomy and physiology in a single imaging session. The co-primary aim of the CORE320 study is to define the per-patient diagnostic accuracy of the combination of coronary CTA and myocardial CTP to detect physiologically significant coronary artery disease compared with (1) the combination of conventional coronary angiography and SPECT-MPI and (2) conventional coronary angiography alone. If successful, the technology could revolutionize the management of patients with symptomatic CAD.<br /> (Copyright © 2011 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Brazil
Canada
Coronary Artery Disease physiopathology
Europe
Female
Hemodynamics
Humans
Japan
Male
Middle Aged
Predictive Value of Tests
Prognosis
Prospective Studies
Radiographic Image Interpretation, Computer-Assisted
Severity of Illness Index
Singapore
United States
Coronary Angiography methods
Coronary Artery Disease diagnostic imaging
Coronary Circulation
Myocardial Perfusion Imaging methods
Research Design
Tomography, X-Ray Computed
Subjects
Details
- Language :
- English
- ISSN :
- 1876-861X
- Volume :
- 5
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular computed tomography
- Publication Type :
- Academic Journal
- Accession number :
- 22146496
- Full Text :
- https://doi.org/10.1016/j.jcct.2011.11.001