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Minimotif Miner 3.0: database expansion and significantly improved reduction of false-positive predictions from consensus sequences.
- Source :
-
Nucleic acids research [Nucleic Acids Res] 2012 Jan; Vol. 40 (Database issue), pp. D252-60. Date of Electronic Publication: 2011 Dec 06. - Publication Year :
- 2012
-
Abstract
- Minimotif Miner (MnM available at http://minimotifminer.org or http://mnm.engr.uconn.edu) is an online database for identifying new minimotifs in protein queries. Minimotifs are short contiguous peptide sequences that have a known function in at least one protein. Here we report the third release of the MnM database which has now grown 60-fold to approximately 300,000 minimotifs. Since short minimotifs are by their nature not very complex we also summarize a new set of false-positive filters and linear regression scoring that vastly enhance minimotif prediction accuracy on a test data set. This online database can be used to predict new functions in proteins and causes of disease.
Details
- Language :
- English
- ISSN :
- 1362-4962
- Volume :
- 40
- Issue :
- Database issue
- Database :
- MEDLINE
- Journal :
- Nucleic acids research
- Publication Type :
- Academic Journal
- Accession number :
- 22146221
- Full Text :
- https://doi.org/10.1093/nar/gkr1189