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QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone.
- Source :
-
Human psychopharmacology [Hum Psychopharmacol] 2012 Jan; Vol. 27 (1), pp. 39-42. Date of Electronic Publication: 2011 Dec 05. - Publication Year :
- 2012
-
Abstract
- Objective: A dose-dependent increase in risk of sudden cardiac death for the antipsychotic drug risperidone was reported. However, few reports have so far addressed QT prolongation associated with the use of risperidone or its major active metabolite, which is also used as a separate antipsychotic drug, paliperidone.<br />Methods: The present study evaluated associations between risperidone metabolism and QT interval in 61 psychiatric patients who had been receiving risperidone for ≥4 weeks at an average dosage of 4.7 mg/day. Plasma risperidone and paliperidone levels were measured and electrocardiographic measurements were also obtained.<br />Results: There was no correlation between risperidone dosage and QTc or plasma risperidone levels and QTc. However, there was a significant positive correlation between plasma paliperidone levels and QTc (r = 0.361; p = 0.004). There was no correlation between age and dose-corrected plasma risperidone levels or between age and QTc. There was a significant positive correlation between age and dose-corrected plasma paliperidone levels (r = 0.290; p = 0.023).<br />Conclusion: Clinically, paliperidone is considered to play a more important role in QT prolongation than risperidone.<br /> (Copyright © 2011 John Wiley & Sons, Ltd.)
- Subjects :
- Adult
Age Factors
Antipsychotic Agents administration & dosage
Antipsychotic Agents pharmacokinetics
Dose-Response Relationship, Drug
Electrocardiography
Female
Humans
Isoxazoles pharmacokinetics
Male
Paliperidone Palmitate
Pyrimidines pharmacokinetics
Risperidone administration & dosage
Risperidone pharmacokinetics
Young Adult
Antipsychotic Agents adverse effects
Isoxazoles adverse effects
Long QT Syndrome chemically induced
Pyrimidines adverse effects
Risperidone adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1077
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Human psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 22144033
- Full Text :
- https://doi.org/10.1002/hup.1258