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Effects of antihypertensive drugs on experimental cerebral ischemia in spontaneously hypertensive rats.
- Source :
-
Japanese journal of pharmacology [Jpn J Pharmacol] 1990 Aug; Vol. 53 (4), pp. 502-5. - Publication Year :
- 1990
-
Abstract
- The effects of antihypertensive drugs on ischemic cerebral damage were investigated using the bilateral carotid artery occlusion (BCAO) model in SHR. Oral budralazine and nifedipine, at doses that increased cerebral blood flow (CBF) in SHR in our previous study (Tanaka, S. et al., Folia Pharmacol, Japan, 87, 1986), significantly improved cerebral energy failure after the BCAO, but prazosin which does not increase CBF had no effect on the energy failure. These results suggest that the amelioration by these antihypertensive drugs of the energy failure after the BCAO results from its CBF-increasing effects in SHR.
- Subjects :
- Adenosine Triphosphate metabolism
Animals
Brain Chemistry drug effects
Carotid Arteries physiology
Cerebrovascular Circulation drug effects
Energy Metabolism drug effects
Hydralazine analogs & derivatives
Hydralazine pharmacology
Lactates metabolism
Male
Nifedipine pharmacology
Pyruvates metabolism
Rats
Rats, Inbred SHR
Antihypertensive Agents pharmacology
Brain Ischemia physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-5198
- Volume :
- 53
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Japanese journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 2214372
- Full Text :
- https://doi.org/10.1254/jjp.53.502