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Subgingival biofilm structure.
- Source :
-
Frontiers of oral biology [Front Oral Biol] 2012; Vol. 15, pp. 1-16. Date of Electronic Publication: 2011 Nov 11. - Publication Year :
- 2012
-
Abstract
- Periodontitis is an inflammatory disease of the oral cavity initiated by a microbial biofilm (or 'dental plaque'). Subgingival biofilms in periodontal pockets are not easily analyzed without the loss of structural integrity. These subgingival plaques are structured communities of microorganisms with great phylogenetic diversity embedded in a self-produced extracellular polymeric matrix. For almost three decades, knowledge of the structure of plaque located below the gingival margin has been limited to landmark studies from the 1970s that were unaware of the breadth of microbial diversity we appreciate now. Only recently has technical progress - combining histology, confocal scanning fluorescent microscopy and fluorescent in situ hybridization to localize the most abundant species from different phyla and species associated with periodontitis - provided new insights into the architecture of subgingival biofilms. This review focuses on the structure and composition of subgingival biofilms and discusses current knowledge on the nature of the extracellular matrix. We describe further structural aspects of 'subgingival' biofilms produced in vitro that are gaining considerable interest as we search for models to investigate biofilm development, resistance to antibiotics, extracellular polymeric matrix composition and function, and reciprocal host-cell-to-biofilm interactions.<br /> (Copyright © 2012 S. Karger AG, Basel.)
- Subjects :
- Bacteria genetics
Bacteria isolation & purification
Biodiversity
DNA, Bacterial analysis
DNA, Bacterial genetics
Extracellular Matrix chemistry
Humans
In Situ Hybridization, Fluorescence
Metabolome
Microbial Consortia
Microscopy, Confocal
Periodontitis microbiology
RNA, Ribosomal, 16S
Signal Transduction
Tooth Root microbiology
Bacteria classification
Biofilms growth & development
Dental Plaque microbiology
Periodontal Pocket microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-2433
- Volume :
- 15
- Database :
- MEDLINE
- Journal :
- Frontiers of oral biology
- Publication Type :
- Academic Journal
- Accession number :
- 22142954
- Full Text :
- https://doi.org/10.1159/000329667