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A microanalytical study of the surfaces of normal, delipidized, and artificially "resurfaced" articular cartilage.
- Source :
-
Connective tissue research [Connect Tissue Res] 2012; Vol. 53 (3), pp. 236-45. Date of Electronic Publication: 2011 Dec 05. - Publication Year :
- 2012
-
Abstract
- The surface amorphous layer of articular cartilage is of primary importance to its load-bearing and lubrication function. This lipid-filled layer is degraded/disrupted or eliminated when cartilage degenerates due to diseases. This article examines further the characteristic of this surface overlay using a combination of microscopy and imaging methods to evaluate the hypothesis that the surface of articular cartilage can be repaired by exposing degraded cartilage to aqueous synthetic lipid mixtures. The preliminary results demonstrate that it is possible to create a new surface layer of phospholipids on the surface of cartilage following artificial lipid removal, but such a layer does not possess enough mechanical strength for physiological function when created with either unsaturated palmitoyl-oleoyl-phosphatidylcholine or saturated dipalmitoyl-phosphatidylcholine component of joint lipid composition alone. We conclude that this may be due to low structural cohesivity, inadequate time of exposure, and the mix/content of lipid in the incubation environment.
- Subjects :
- Animals
Biomechanical Phenomena
Cartilage, Articular anatomy & histology
Cartilage, Articular chemistry
Cattle
Elasticity drug effects
Elasticity physiology
Lubrication
Membrane Lipids chemistry
Membrane Lipids pharmacology
Microscopy, Atomic Force
Phospholipids chemistry
Phospholipids pharmacology
Solvents
Surface Properties
Surface-Active Agents chemistry
Surface-Active Agents pharmacology
Time Factors
Weight-Bearing
Cartilage, Articular physiology
Membrane Lipids physiology
Phospholipids physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1607-8438
- Volume :
- 53
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Connective tissue research
- Publication Type :
- Academic Journal
- Accession number :
- 22141914
- Full Text :
- https://doi.org/10.3109/03008207.2011.630764