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Modulation of TCRβ surface expression during TCR revision.
- Source :
-
Cellular immunology [Cell Immunol] 2012; Vol. 272 (2), pp. 124-9. Date of Electronic Publication: 2011 Nov 15. - Publication Year :
- 2012
-
Abstract
- TCR revision is a tolerance mechanism by which self-reactive TCRs expressed by mature CD4(+) peripheral T cells are replaced by receptors encoded by genes generated by post-thymic DNA rearrangement. The downmodulation of surface TCR expression initiates TCR revision, and serves as a likely trigger for the induction of the recombinase machinery. We show here in a Vβ5 transgenic mouse model system that downregulation of the self-reactive transgene-encoded TCR is not maintained by transgene loss or diminished transcription or translation. The downregulation of surface TCR expression likely occurs in two stages, only one of which requires tolerogen expression.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
CD4-Positive T-Lymphocytes metabolism
Down-Regulation genetics
Gene Expression genetics
Immune Tolerance genetics
Mice
Mice, Transgenic
Receptors, Antigen, T-Cell, alpha-beta metabolism
Transgenes genetics
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Receptors, Antigen, T-Cell, alpha-beta biosynthesis
Receptors, Antigen, T-Cell, alpha-beta genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2163
- Volume :
- 272
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cellular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 22138498
- Full Text :
- https://doi.org/10.1016/j.cellimm.2011.10.022