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CXCL12: a new player in coronary disease identified through human genetics.
- Source :
-
Trends in cardiovascular medicine [Trends Cardiovasc Med] 2010 Aug; Vol. 20 (6), pp. 204-9. - Publication Year :
- 2010
-
Abstract
- Genome-wide association studies (GWAS) of more than 100,000 people have revealed novel loci associated with coronary artery disease and myocardial infarction that present exciting opportunities to discover novel disease pathways. One such recently identified locus is on chromosome 10q11, near the gene for the chemokine CXCL12, which has been implicated in cardiovascular disease in both mouse and human studies. These GWAS demonstrate that CXCL12 may emerge as a potential therapeutic target for atherosclerosis and thrombosis.<br /> (Copyright © 2010 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Arteriosclerosis enzymology
Arteriosclerosis genetics
Arteriosclerosis pathology
Chemokine CXCL12 metabolism
Coronary Artery Disease drug therapy
Coronary Artery Disease pathology
Disease Models, Animal
Genome-Wide Association Study
Humans
Myocardial Infarction drug therapy
Myocardial Infarction pathology
Chemokine CXCL12 genetics
Coronary Artery Disease genetics
Myocardial Infarction genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2615
- Volume :
- 20
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Trends in cardiovascular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22137643
- Full Text :
- https://doi.org/10.1016/j.tcm.2011.08.002