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Effects of the liver volume and donor steatosis on errors in the estimated standard liver volume.
- Source :
-
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society [Liver Transpl] 2011 Dec; Vol. 17 (12), pp. 1437-42. - Publication Year :
- 2011
-
Abstract
- An accurate assessment of donor and recipient liver volumes is essential in living donor liver transplantation. Many liver donors are affected by mild to moderate steatosis, and steatotic livers are known to have larger volumes. This study analyzes errors in liver volume estimation by commonly used formulas and the effects of donor steatosis on these errors. Three hundred twenty-five Asian donors who underwent right lobe donor hepatectomy were the subjects of this study. The percentage differences between the liver volumes from computed tomography (CT) and the liver volumes estimated with each formula (ie, the error percentages) were calculated. Five popular formulas were tested. The degrees of steatosis were categorized as follows: no steatosis [n = 178 (54.8%)], ≤ 10% steatosis [n = 128 (39.4%)], and >10% to 20% steatosis [n = 19 (5.8%)]. The median errors ranged from 0.6% (7 mL) to 24.6% (360 mL). The lowest was seen with the locally derived formula. All the formulas showed a significant association between the error percentage and the CT liver volume (P < 0.001). Overestimation was seen with smaller liver volumes, whereas underestimation was seen with larger volumes. The locally derived formula was most accurate when the liver volume was 1001 to 1250 mL. A multivariate analysis showed that the estimation error was dependent on the liver volume (P = 0.001) and the anthropometric measurement that was used in the calculation (P < 0.001) rather than steatosis (P ≥ 0.07). In conclusion, all the formulas have a similar pattern of error that is possibly related to the anthropometric measurement. Clinicians should be aware of this pattern of error and the liver volume with which their formula is most accurate.<br /> (Copyright © 2011 American Association for the Study of Liver Diseases.)
- Subjects :
- Adolescent
Adult
Biopsy
Fatty Liver diagnostic imaging
Hong Kong
Humans
Linear Models
Liver diagnostic imaging
Logistic Models
Middle Aged
Models, Biological
Multivariate Analysis
Organ Size
Predictive Value of Tests
Reproducibility of Results
Severity of Illness Index
Tomography, Spiral Computed
Young Adult
Fatty Liver pathology
Hepatectomy
Liver pathology
Liver surgery
Liver Transplantation
Living Donors
Subjects
Details
- Language :
- English
- ISSN :
- 1527-6473
- Volume :
- 17
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
- Publication Type :
- Academic Journal
- Accession number :
- 22127780
- Full Text :
- https://doi.org/10.1002/lt.22430