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Scleroderma and L-tryptophan: a possible explanation of the eosinophilia-myalgia syndrome.
- Source :
-
Journal of the American Academy of Dermatology [J Am Acad Dermatol] 1990 Sep; Vol. 23 (3 Pt 1), pp. 451-7. - Publication Year :
- 1990
-
Abstract
- Scleroderma developed in six women who were taking L-tryptophan. Fasciitis and morphea were most common, but one patient had pleural effusion, hypertension, and signs of cardiac and kidney failure. In five patients the biopsy findings were characteristic of scleroderma; the sixth patient had Crohn's disease and developed fasciitis; her biopsy specimen showed inflammatory arteritis. All patients' conditions improved after cessation of their L-tryptophan intake, initiation of corticosteroid therapy, or both. These findings confirm previous data that show altered tryptophan-kynurenine metabolism in some patients with scleroderma and fasciitis, particularly with tryptophan loading.
- Subjects :
- Adult
Aged
Eosinophilia pathology
Fasciitis pathology
Female
Humans
Kynurenine urine
Middle Aged
Myositis pathology
Prednisone administration & dosage
Prednisone therapeutic use
Scleroderma, Systemic pathology
Skin pathology
Syndrome
Tryptophan administration & dosage
Tryptophan metabolism
Eosinophilia chemically induced
Scleroderma, Systemic chemically induced
Tryptophan adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0190-9622
- Volume :
- 23
- Issue :
- 3 Pt 1
- Database :
- MEDLINE
- Journal :
- Journal of the American Academy of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 2212143
- Full Text :
- https://doi.org/10.1016/0190-9622(90)70239-e