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Association analysis between the -2518MCP-1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population.
- Source :
-
Journal of periodontal research [J Periodontal Res] 2012 Jun; Vol. 47 (3), pp. 286-92. Date of Electronic Publication: 2011 Nov 27. - Publication Year :
- 2012
-
Abstract
- Background and Objective: It has been suggested that aggressive periodontitis has a genetic basis. Monocyte chemoattractant protein 1 (MCP-1) plays a critical role in the recruitment of monocytes and the development of periodontitis. The -2518MCP-1(A/G) polymorphism has been implicated as a risk or susceptibility factor for a variety of autoimmune conditions and inflammatory diseases. The intent of this investigation was to study whether the -2518MCP-1(A/G) polymorphism is associated with generalized aggressive periodontitis in the Chinese population.<br />Material and Methods: One hundred and twenty-four patients with generalized aggressive periodontitis and 94 healthy subjects were included in this case-control study. Genomic DNA was isolated from a peripheral blood sample obtained from each subject. Gene polymorphisms of -2518MCP-1(A/G) were analyzed by a standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. A logistic regression analysis was performed to test the association between the -2518MCP-1(A/G) genotype (alleles) and generalized aggressive periodontitis with adjustment of the major covariates (gender, age and smoking status).<br />Results: There was no significant association of the -2518MCP-1(A/G) polymorphism with generalized aggressive periodontitis in the unstratified subjects. However, when patients were stratified by gender, the frequency of the G(+) genotype was significantly lower in female patients with generalized aggressive periodontitis compared with female controls (p = 0.036, adjusted odds ratio = 0.3, 95% CI: 0.1-0.9). In female patients with generalized aggressive periodontitis, the probing pocket depth was larger in subjects with the AA genotype than in subjects with the G(+) genotype (5.07 mm vs. 4.30 mm; Z = -2.470, p = 0.014).<br />Conclusion: The polymorphisms of -2518MCP-1 may play an important role in determining generalized aggressive periodontitis susceptibility in this cohort of Chinese women.<br /> (© 2011 John Wiley & Sons A/S.)
- Subjects :
- Adult
Aggressive Periodontitis classification
Aggressive Periodontitis immunology
Case-Control Studies
Chemokine CCL2 blood
China
Cohort Studies
Female
Gene Frequency genetics
Genetic Predisposition to Disease genetics
Genotype
Humans
Male
Periodontal Attachment Loss classification
Periodontal Attachment Loss genetics
Periodontal Pocket classification
Periodontal Pocket genetics
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length genetics
Risk Factors
Sex Factors
Smoking
Adenine
Aggressive Periodontitis genetics
Chemokine CCL2 genetics
Guanine
Polymorphism, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0765
- Volume :
- 47
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of periodontal research
- Publication Type :
- Academic Journal
- Accession number :
- 22117820
- Full Text :
- https://doi.org/10.1111/j.1600-0765.2011.01426.x