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Recommendations for the optimal management of early and advanced urothelial carcinoma.
- Source :
-
Cancer treatment reviews [Cancer Treat Rev] 2012 Aug; Vol. 38 (5), pp. 431-41. Date of Electronic Publication: 2011 Nov 23. - Publication Year :
- 2012
-
Abstract
- The field of urothelial carcinoma has shown considerable advances in terms of diagnosis, staging, and treatment. The increasing knowledge of molecular pathways and genes involved in the occurrence of this tumor has encouraged the search for new, more effective and less toxic therapies, and has prompted the design and development of clinical trials. However, the speed at which results are published makes it difficult for clinicians to cover the vast amount of information available. Moreover, in clinical practice some gaps remain concerning treatment options for patients who have progressed after first-line cisplatin-based combinations, who cannot tolerate cisplatin-based chemotherapy, or who have received platinum-based neoadjuvant or adjuvant therapy, and thus cannot be offered this option on disease progression. The purpose of this review is to issue a series of recommendations on the optimal management of early and advanced urothelial carcinoma based on current evidence and the available updated guidelines.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents therapeutic use
Carcinoma, Transitional Cell diagnosis
Carcinoma, Transitional Cell genetics
Carcinoma, Transitional Cell pathology
Chemotherapy, Adjuvant
Humans
Mutation
Neoadjuvant Therapy
Urinary Bladder Neoplasms diagnosis
Urinary Bladder Neoplasms genetics
Urinary Bladder Neoplasms pathology
Carcinoma, Transitional Cell therapy
Urinary Bladder Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1967
- Volume :
- 38
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer treatment reviews
- Publication Type :
- Academic Journal
- Accession number :
- 22116017
- Full Text :
- https://doi.org/10.1016/j.ctrv.2011.10.004