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Compartmentalization of cerebral cortical germinal zones in a lissencephalic primate and gyrencephalic rodent.
- Source :
-
Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2012 Feb; Vol. 22 (2), pp. 482-92. Date of Electronic Publication: 2011 Nov 23. - Publication Year :
- 2012
-
Abstract
- Previous studies of macaque and human cortices identified cytoarchitectonically distinct germinal zones; the ventricular zone inner subventricular zone (ISVZ), and outer subventricular zone (OSVZ). To date, the OSVZ has only been described in gyrencephalic brains, separated from the ISVZ by an inner fiber layer and considered a milestone that triggered increased neocortical neurogenesis. However, this observation has only been assessed in a handful of species without the identification of the different progenitor populations. We examined the Amazonian rodent agouti (Dasyprocta agouti) and the marmoset monkey (Callithrix jacchus) to further understand relationships among progenitor compartmentalization, proportions of various cortical progenitors, and degree of cortical folding. We identified a similar cytoarchitectonic distinction between the OSVZ and ISVZ at midgestation in both species. In the marmoset, we quantified the ventricular and abventricular divisions and observed similar proportions as previously described for the human and ferret brains. The proportions of radial glia, intermediate progenitors, and outer radial glial cell (oRG) populations were similar in midgestation lissencephalic marmoset as in gyrencephalic human or ferret. Our findings suggest that cytoarchitectonic subdivisions of SVZ are an evolutionary trend and not a primate specific feature, and a large population of oRG can be seen regardless of cortical folding.
- Subjects :
- Age Factors
Animals
Animals, Newborn
Brain Mapping
Callithrix anatomy & histology
Cell Proliferation
Cerebral Cortex embryology
Cerebral Cortex growth & development
Cerebral Ventricles embryology
Cerebral Ventricles growth & development
Embryo, Mammalian
Gene Expression Regulation, Developmental
Histones
Ki-67 Antigen
Nerve Tissue Proteins metabolism
Neuroglia
Neurons
Rodentia anatomy & histology
SOXB1 Transcription Factors metabolism
Stem Cells
Cerebral Cortex anatomy & histology
Cerebral Ventricles cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2199
- Volume :
- 22
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cerebral cortex (New York, N.Y. : 1991)
- Publication Type :
- Academic Journal
- Accession number :
- 22114081
- Full Text :
- https://doi.org/10.1093/cercor/bhr312