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Nine-month results of intravitreal bevacizumab versus triamcinolone for the treatment of diffuse diabetic macular oedema: a retrospective analysis.
- Source :
-
Acta ophthalmologica [Acta Ophthalmol] 2011 Dec; Vol. 89 (8), pp. 769-73. - Publication Year :
- 2011
-
Abstract
- Objective: To compare efficacy of intravitreal bevacizumab versus triamcinolone in the treatment of diffuse diabetic macular oedema (DME).<br />Methods: This retrospective nonrandomized study includes 60 patients with diffuse DME treated with at least one intravitreal triamcinolone injection (ITA) or intravitreal bevacizumab injection (IBe). Regression analysis was performed for pretreatment, glycosylated haemoglobin level, visual acuity (VA) at baseline and central macular thickness (CMT) at baseline.<br />Results: After 1-, 3-, 6- and 9-month follow-up, there was no significant change in either VA or CMT treatment in the ITA and IBe groups. There was no statistically significant difference between the two treatment groups. Changes in CMT and VA in the subgroups were not significant. Only predictive factor independent of HbA1c level and VA was CMT at baseline in both treatment groups. The thicker CMT at baseline, the higher was reduction in CMT. After 1 month, the IBe group had a significantly higher decrement than the ITA group.<br />Conclusion: In our study collective, neither IBe nor ITA treatment was able to improve VA during follow-up, significantly. CMT was reduced in both treatment groups, however not significantly. Our data demonstrates that reduction in CMT with either IBe or ITA treatment was significantly influenced by degree of CMT at baseline.<br /> (© 2010 The Authors. Journal compilation © 2010 Acta Ophthalmol.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Bevacizumab
Diabetic Retinopathy physiopathology
Female
Follow-Up Studies
Glycated Hemoglobin metabolism
Humans
Intravitreal Injections
Macular Edema physiopathology
Male
Middle Aged
Retrospective Studies
Tomography, Optical Coherence
Treatment Outcome
Vascular Endothelial Growth Factor A antagonists & inhibitors
Visual Acuity physiology
Angiogenesis Inhibitors administration & dosage
Antibodies, Monoclonal, Humanized administration & dosage
Diabetic Retinopathy drug therapy
Glucocorticoids administration & dosage
Macular Edema drug therapy
Triamcinolone Acetonide administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1755-3768
- Volume :
- 89
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Acta ophthalmologica
- Publication Type :
- Academic Journal
- Accession number :
- 22112018
- Full Text :
- https://doi.org/10.1111/j.1755-3768.2009.01823.x