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Hemolytic activity of a lipid material obtained from peroxidized microsomes.

Authors :
Willis RJ
Pesh-Imam M
Recknagel RO
Source :
Research communications in chemical pathology and pharmacology [Res Commun Chem Pathol Pharmacol] 1977 Nov; Vol. 18 (3), pp. 433-7.
Publication Year :
1977

Abstract

Lipid peroxidation was induced in rat liver microsomes by the addition of NADPH. When mixed with red cells in the presence of EDTA, these peroxidized microsomes caused hemolysis. All of the hemolytic activity of peroxidized microsomes could be extracted with lipid solvents and recovered as an aqueous lipid emulsion.

Subjects

Subjects :
Animals
In Vitro Techniques
Male
Microsomes, Liver drug effects
NADP metabolism
Peroxides pharmacology
Rats
Hemolysis drug effects
Lipids pharmacology
Microsomes, Liver physiology

Details

Language :
English
ISSN :
0034-5164
Volume :
18
Issue :
3
Database :
MEDLINE
Journal :
Research communications in chemical pathology and pharmacology
Publication Type :
Academic Journal
Accession number :
22110

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Authors Abstract Subjects Details