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Androgen receptor co-activators in the regulation of cellular events in prostate cancer.
- Source :
-
World journal of urology [World J Urol] 2012 Jun; Vol. 30 (3), pp. 297-302. Date of Electronic Publication: 2011 Nov 22. - Publication Year :
- 2012
-
Abstract
- Objectives: Androgen receptor (AR) action in benign and malignant tissue is potentiated by a number of co-regulatory proteins that may interact with one or more receptor domains. With improvement of research methodologies, it became possible to detect a number of co-activators whose expression is increased in prostate cancer tissue.<br />Methods: Manuscripts describing prostate cancer-relevant regulation of cellular events by co-activators are selected and summarized.<br />Results: AR co-activators may regulate histone modification, proteasomal degradation, chaperones, sumoylation, chromatin remodeling, and cytoskeleton. Some of them (TIF-2) are up-regulated by androgens, whereas the expression of others increases during androgen ablation (p300, CBP, and Tip60). Most co-factors are important for the stimulation of cellular proliferation, although in some cases (ART-27), they act as tumor suppressors and are deleted in prostate cancer tissue. In addition to stimulating AR, some co-activators suppress apoptosis in prostate cancer cells that do not express the AR (p300 and SRC-3). It was recently shown that the inhibition of p300 slows down proliferation, stimulates apoptosis, and inhibits migration and invasion.<br />Conclusions: Co-factors whose down-regulation results in the alterations of multiple cellular functions may be valid targets for novel therapies in advanced prostate cancer.
Details
- Language :
- English
- ISSN :
- 1433-8726
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- World journal of urology
- Publication Type :
- Academic Journal
- Accession number :
- 22105110
- Full Text :
- https://doi.org/10.1007/s00345-011-0797-6