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National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach.
- Source :
-
Acta neuropathologica [Acta Neuropathol] 2012 Jan; Vol. 123 (1), pp. 1-11. Date of Electronic Publication: 2011 Nov 20. - Publication Year :
- 2012
-
Abstract
- We present a practical guide for the implementation of recently revised National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease (AD). Major revisions from previous consensus criteria are: (1) recognition that AD neuropathologic changes may occur in the apparent absence of cognitive impairment, (2) an "ABC" score for AD neuropathologic change that incorporates histopathologic assessments of amyloid β deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C), and (3) more detailed approaches for assessing commonly co-morbid conditions such as Lewy body disease, vascular brain injury, hippocampal sclerosis, and TAR DNA binding protein (TDP)-43 immunoreactive inclusions. Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations.
- Subjects :
- Cerebrovascular Disorders classification
Cerebrovascular Disorders pathology
Cerebrovascular Trauma classification
DNA-Binding Proteins metabolism
Hippocampus pathology
Humans
Lewy Body Disease classification
Lewy Body Disease pathology
National Institute on Aging (U.S.)
Sclerosis classification
United States
Alzheimer Disease pathology
Brain pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0533
- Volume :
- 123
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta neuropathologica
- Publication Type :
- Academic Journal
- Accession number :
- 22101365
- Full Text :
- https://doi.org/10.1007/s00401-011-0910-3